Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2962819..2963290 Replicon chromosome
Accession NZ_CP124515
Organism Escherichia coli strain AVS0282

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP70_RS14595 Protein ID WP_001303511.1
Coordinates 2963012..2963290 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP70_RS14590 Protein ID WP_001302048.1
Coordinates 2962819..2963010 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP70_RS14520 (2957886) 2957886..2958053 - 168 WP_000207997.1 hypothetical protein -
QJP70_RS14525 (2958064) 2958064..2958327 - 264 WP_000224216.1 hypothetical protein -
QJP70_RS14530 (2958329) 2958329..2958547 - 219 WP_001142588.1 DUF4014 family protein -
QJP70_RS14535 (2958549) 2958549..2958764 - 216 WP_000510387.1 hypothetical protein -
QJP70_RS14540 (2958765) 2958765..2959124 - 360 WP_001289986.1 hypothetical protein -
QJP70_RS14545 (2959121) 2959121..2959297 - 177 WP_021534704.1 hypothetical protein -
QJP70_RS14550 (2959290) 2959290..2959472 - 183 WP_001224665.1 hypothetical protein -
QJP70_RS14555 (2959601) 2959601..2959912 - 312 WP_021534703.1 hypothetical protein -
QJP70_RS14560 (2959905) 2959905..2960159 - 255 WP_000004322.1 hypothetical protein -
QJP70_RS14565 (2960156) 2960156..2960578 - 423 WP_021534702.1 DUF977 family protein -
QJP70_RS14570 (2960619) 2960619..2961581 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP70_RS14575 (2961604) 2961604..2962029 - 426 WP_000693943.1 toxin YdaT family protein -
QJP70_RS14580 (2962026) 2962026..2962328 - 303 WP_000172738.1 transcriptional regulator -
QJP70_RS14585 (2962427) 2962427..2962798 + 372 WP_001169687.1 hypothetical protein -
QJP70_RS14590 (2962819) 2962819..2963010 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP70_RS14595 (2963012) 2963012..2963290 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP70_RS14600 (2963582) 2963582..2963734 + 153 WP_000380313.1 DUF1391 family protein -
QJP70_RS14605 (2963746) 2963746..2964084 + 339 WP_000394541.1 hypothetical protein -
QJP70_RS14610 (2964073) 2964073..2964267 - 195 WP_001295058.1 hypothetical protein -
QJP70_RS14615 (2964834) 2964834..2965022 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP70_RS14620 (2965019) 2965019..2965207 + 189 WP_000199480.1 DUF1482 family protein -
QJP70_RS14625 (2965303) 2965303..2967774 + 2472 WP_032284123.1 exonuclease -
QJP70_RS14630 (2967836) 2967836..2968105 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2915496..2976360 60864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280770 WP_001303511.1 NZ_CP124515:2963012-2963290 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280770 WP_001302048.1 NZ_CP124515:2962819-2963010 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References