Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4147151..4147727 Replicon chromosome
Accession NZ_CP124513
Organism Escherichia coli strain AVS0366

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP86_RS20210 Protein ID WP_001297643.1
Coordinates 4147440..4147727 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP86_RS20205 Protein ID WP_000063156.1
Coordinates 4147151..4147453 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP86_RS20190 (4143747) 4143747..4145897 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP86_RS20195 (4145947) 4145947..4146150 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP86_RS20200 (4146161) 4146161..4147117 + 957 WP_001297640.1 GTPase -
QJP86_RS20205 (4147151) 4147151..4147453 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP86_RS20210 (4147440) 4147440..4147727 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP86_RS20215 (4147926) 4147926..4148623 - 698 Protein_3962 IS1 family transposase -
QJP86_RS20220 (4148680) 4148680..4148775 + 96 Protein_3963 dienelactone hydrolase family protein -
QJP86_RS20225 (4148921) 4148921..4150153 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP86_RS20230 (4150194) 4150194..4151474 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280753 WP_001297643.1 NZ_CP124513:c4147727-4147440 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp


Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280753 WP_000063156.1 NZ_CP124513:c4147453-4147151 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829GEV9


Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References