Detailed information of TA system TA280751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3807905..3809594
• Replicon: chromosome
• Accession: NZ_CP124513
• Organism: Escherichia coli strain AVS0366

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP86_RS18595
• Protein ID: WP_000365807.1
• Coordinates: 3807905..3808825 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP86_RS18600
• Protein ID: WP_001295795.1
• Coordinates: 3808812..3809594 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP86_RS18555 (3803378)	3803378..3804088	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP86_RS18560 (3804395)	3804395..3804724	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP86_RS18565 (3804736)	3804736..3804902	-	167	Protein_3643	tail fiber assembly protein	-
QJP86_RS18570 (3804973)	3804973..3805587	-	615	WP_001019923.1	YagU family protein	-
QJP86_RS18575 (3805802)	3805802..3805987	-	186	WP_000146240.1	hypothetical protein	-
QJP86_RS18580 (3806036)	3806036..3806194	+	159	Protein_3646	integrase	-
QJP86_RS18585 (3806421)	3806421..3806756	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP86_RS18590 (3806964)	3806964..3807740	+	777	WP_000171155.1	site-specific integrase	-
QJP86_RS18595 (3807905)	3807905..3808825	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP86_RS18600 (3808812)	3808812..3809594	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP86_RS18605 (3809878)	3809878..3812976	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3767692..3816657	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280751 WP_000365807.1 NZ_CP124513:c3808825-3807905 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280751 WP_001295795.1 NZ_CP124513:c3809594-3808812 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0