Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3624616..3625234 Replicon chromosome
Accession NZ_CP124513
Organism Escherichia coli strain AVS0366

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP86_RS17735 Protein ID WP_001291435.1
Coordinates 3625016..3625234 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP86_RS17730 Protein ID WP_000344800.1
Coordinates 3624616..3624990 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP86_RS17720 (3619705) 3619705..3620898 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP86_RS17725 (3620921) 3620921..3624070 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP86_RS17730 (3624616) 3624616..3624990 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP86_RS17735 (3625016) 3625016..3625234 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP86_RS17740 (3625407) 3625407..3625958 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP86_RS17745 (3626074) 3626074..3626544 + 471 WP_000136192.1 YlaC family protein -
QJP86_RS17750 (3626708) 3626708..3628258 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP86_RS17755 (3628300) 3628300..3628653 - 354 WP_000878147.1 DUF1428 family protein -
QJP86_RS17765 (3629032) 3629032..3629343 + 312 WP_000409908.1 MGMT family protein -
QJP86_RS17770 (3629374) 3629374..3629946 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280750 WP_001291435.1 NZ_CP124513:3625016-3625234 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280750 WP_000344800.1 NZ_CP124513:3624616-3624990 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References