Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2956591..2957062 Replicon chromosome
Accession NZ_CP124513
Organism Escherichia coli strain AVS0366

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP86_RS14525 Protein ID WP_001303511.1
Coordinates 2956784..2957062 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP86_RS14520 Protein ID WP_001302048.1
Coordinates 2956591..2956782 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP86_RS14450 (2951658) 2951658..2951825 - 168 WP_000207997.1 hypothetical protein -
QJP86_RS14455 (2951836) 2951836..2952099 - 264 WP_000224216.1 hypothetical protein -
QJP86_RS14460 (2952101) 2952101..2952319 - 219 WP_001142588.1 DUF4014 family protein -
QJP86_RS14465 (2952321) 2952321..2952536 - 216 WP_000510387.1 hypothetical protein -
QJP86_RS14470 (2952537) 2952537..2952896 - 360 WP_001289986.1 hypothetical protein -
QJP86_RS14475 (2952893) 2952893..2953069 - 177 WP_021534704.1 hypothetical protein -
QJP86_RS14480 (2953062) 2953062..2953244 - 183 WP_001224665.1 hypothetical protein -
QJP86_RS14485 (2953373) 2953373..2953684 - 312 WP_021534703.1 hypothetical protein -
QJP86_RS14490 (2953677) 2953677..2953931 - 255 WP_000004322.1 hypothetical protein -
QJP86_RS14495 (2953928) 2953928..2954350 - 423 WP_021534702.1 DUF977 family protein -
QJP86_RS14500 (2954391) 2954391..2955353 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP86_RS14505 (2955376) 2955376..2955801 - 426 WP_000693943.1 toxin YdaT family protein -
QJP86_RS14510 (2955798) 2955798..2956100 - 303 WP_000172738.1 transcriptional regulator -
QJP86_RS14515 (2956199) 2956199..2956570 + 372 WP_001169687.1 hypothetical protein -
QJP86_RS14520 (2956591) 2956591..2956782 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP86_RS14525 (2956784) 2956784..2957062 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP86_RS14530 (2957354) 2957354..2957506 + 153 WP_000380313.1 DUF1391 family protein -
QJP86_RS14535 (2957518) 2957518..2957856 + 339 WP_000394541.1 hypothetical protein -
QJP86_RS14540 (2957845) 2957845..2958039 - 195 WP_001295058.1 hypothetical protein -
QJP86_RS14545 (2958606) 2958606..2958794 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP86_RS14550 (2958791) 2958791..2958979 + 189 WP_000199480.1 DUF1482 family protein -
QJP86_RS14555 (2959075) 2959075..2961546 + 2472 WP_032284123.1 exonuclease -
QJP86_RS14560 (2961608) 2961608..2961877 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2910744..2970132 59388
- inside Prophage sitABCD - 2849355..2970132 120777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280748 WP_001303511.1 NZ_CP124513:2956784-2957062 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280748 WP_001302048.1 NZ_CP124513:2956591-2956782 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References