Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3257495..3258295 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP59_RS15970 Protein ID WP_000342452.1
Coordinates 3257768..3258295 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP59_RS15965 Protein ID WP_001277107.1
Coordinates 3257495..3257761 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS15945 (3253154) 3253154..3253822 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJP59_RS15950 (3253815) 3253815..3254873 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QJP59_RS15955 (3255118) 3255118..3255972 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP59_RS15960 (3256243) 3256243..3257346 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP59_RS15965 (3257495) 3257495..3257761 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP59_RS15970 (3257768) 3257768..3258295 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP59_RS15975 (3258292) 3258292..3258675 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP59_RS15980 (3259098) 3259098..3260207 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP59_RS15985 (3260255) 3260255..3261181 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP59_RS15990 (3261178) 3261178..3262455 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP59_RS15995 (3262452) 3262452..3263219 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280728 WP_000342452.1 NZ_CP124511:3257768-3258295 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280728 WP_001277107.1 NZ_CP124511:3257495-3257761 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References