280723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1958576..1959126 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag QJP59_RS09905 Protein ID WP_001160966.1
Coordinates 1958576..1958890 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJP59_RS09910 Protein ID WP_000125566.1
Coordinates 1958893..1959126 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS09880 (1954251) 1954251..1955537 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QJP59_RS09885 (1955537) 1955537..1956526 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJP59_RS09890 (1956523) 1956523..1957344 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJP59_RS09895 (1957347) 1957347..1957724 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJP59_RS09900 (1957731) 1957731..1958579 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJP59_RS09905 (1958576) 1958576..1958890 - 315 WP_001160966.1 CcdB family protein Toxin
QJP59_RS09910 (1958893) 1958893..1959126 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJP59_RS09915 (1959212) 1959212..1959691 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJP59_RS09920 (1959883) 1959883..1961745 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
QJP59_RS09925 (1961738) 1961738..1962268 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJP59_RS09930 (1962376) 1962376..1963707 - 1332 WP_001183207.1 MFS transporter -
QJP59_RS09935 (1963766) 1963766..1964053 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T280723 WP_001160966.1 NZ_CP124511:c1958890-1958576 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT280723 WP_000125566.1 NZ_CP124511:c1959126-1958893 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References