Detailed information of TA system TA280722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1729041..1730730
• Replicon: chromosome
• Accession: NZ_CP124511
• Organism: Escherichia coli strain AVS0501

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP59_RS08830
• Protein ID: WP_000365807.1
• Coordinates: 1729041..1729961 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP59_RS08835
• Protein ID: WP_001295795.1
• Coordinates: 1729948..1730730 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP59_RS08790 (1724514)	1724514..1725224	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP59_RS08795 (1725531)	1725531..1725860	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP59_RS08800 (1725872)	1725872..1726038	-	167	Protein_1732	tail fiber assembly protein	-
QJP59_RS08805 (1726109)	1726109..1726723	-	615	WP_001019923.1	YagU family protein	-
QJP59_RS08810 (1726938)	1726938..1727123	-	186	WP_000146240.1	hypothetical protein	-
QJP59_RS08815 (1727172)	1727172..1727330	+	159	Protein_1735	integrase	-
QJP59_RS08820 (1727557)	1727557..1727892	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP59_RS08825 (1728100)	1728100..1728876	+	777	WP_000171155.1	site-specific integrase	-
QJP59_RS08830 (1729041)	1729041..1729961	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP59_RS08835 (1729948)	1729948..1730730	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP59_RS08840 (1731014)	1731014..1734112	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	1688828..1737793	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280722 WP_000365807.1 NZ_CP124511:c1729961-1729041 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280722 WP_001295795.1 NZ_CP124511:c1730730-1729948 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0