Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1545752..1546370 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP59_RS07970 Protein ID WP_001291435.1
Coordinates 1546152..1546370 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP59_RS07965 Protein ID WP_000344800.1
Coordinates 1545752..1546126 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS07955 (1540841) 1540841..1542034 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP59_RS07960 (1542057) 1542057..1545206 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP59_RS07965 (1545752) 1545752..1546126 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP59_RS07970 (1546152) 1546152..1546370 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP59_RS07975 (1546543) 1546543..1547094 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP59_RS07980 (1547210) 1547210..1547680 + 471 WP_000136192.1 YlaC family protein -
QJP59_RS07985 (1547844) 1547844..1549394 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP59_RS07990 (1549436) 1549436..1549789 - 354 WP_000878147.1 DUF1428 family protein -
QJP59_RS08000 (1550168) 1550168..1550479 + 312 WP_000409908.1 MGMT family protein -
QJP59_RS08005 (1550510) 1550510..1551082 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280721 WP_001291435.1 NZ_CP124511:1546152-1546370 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280721 WP_000344800.1 NZ_CP124511:1545752-1546126 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References