Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 841409..841880 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP59_RS04505 Protein ID WP_001303511.1
Coordinates 841602..841880 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP59_RS04500 Protein ID WP_001302048.1
Coordinates 841409..841600 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS04430 (836476) 836476..836643 - 168 WP_000207997.1 hypothetical protein -
QJP59_RS04435 (836654) 836654..836917 - 264 WP_000224216.1 hypothetical protein -
QJP59_RS04440 (836919) 836919..837137 - 219 WP_001142588.1 DUF4014 family protein -
QJP59_RS04445 (837139) 837139..837354 - 216 WP_000510387.1 hypothetical protein -
QJP59_RS04450 (837355) 837355..837714 - 360 WP_001289986.1 hypothetical protein -
QJP59_RS04455 (837711) 837711..837887 - 177 WP_021534704.1 hypothetical protein -
QJP59_RS04460 (837880) 837880..838062 - 183 WP_001224665.1 hypothetical protein -
QJP59_RS04465 (838191) 838191..838502 - 312 WP_021534703.1 hypothetical protein -
QJP59_RS04470 (838495) 838495..838749 - 255 WP_000004322.1 hypothetical protein -
QJP59_RS04475 (838746) 838746..839168 - 423 WP_021534702.1 DUF977 family protein -
QJP59_RS04480 (839209) 839209..840171 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP59_RS04485 (840194) 840194..840619 - 426 WP_000693943.1 toxin YdaT family protein -
QJP59_RS04490 (840616) 840616..840918 - 303 WP_000172738.1 transcriptional regulator -
QJP59_RS04495 (841017) 841017..841388 + 372 WP_001169687.1 hypothetical protein -
QJP59_RS04500 (841409) 841409..841600 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP59_RS04505 (841602) 841602..841880 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP59_RS04510 (842172) 842172..842324 + 153 WP_000380313.1 DUF1391 family protein -
QJP59_RS04515 (842336) 842336..842674 + 339 WP_000394541.1 hypothetical protein -
QJP59_RS04520 (842663) 842663..842857 - 195 WP_001295058.1 hypothetical protein -
QJP59_RS04525 (843424) 843424..843612 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP59_RS04530 (843609) 843609..843797 + 189 WP_000199480.1 DUF1482 family protein -
QJP59_RS04535 (843893) 843893..846364 + 2472 WP_032284123.1 exonuclease -
QJP59_RS04540 (846426) 846426..846695 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 794086..854950 60864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280719 WP_001303511.1 NZ_CP124511:841602-841880 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280719 WP_001302048.1 NZ_CP124511:841409-841600 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References