Detailed information of TA system TA280707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3729610..3731299
• Replicon: chromosome
• Accession: NZ_CP124508
• Organism: Escherichia coli strain AVS0068

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB02_RS18195
• Protein ID: WP_000365807.1
• Coordinates: 3729610..3730530 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB02_RS18200
• Protein ID: WP_001295795.1
• Coordinates: 3730517..3731299 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB02_RS18155 (3725083)	3725083..3725793	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJB02_RS18160 (3726100)	3726100..3726429	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB02_RS18165 (3726441)	3726441..3726607	-	167	Protein_3563	tail fiber assembly protein	-
QJB02_RS18170 (3726678)	3726678..3727292	-	615	WP_001019923.1	YagU family protein	-
QJB02_RS18175 (3727507)	3727507..3727692	-	186	WP_000146240.1	hypothetical protein	-
QJB02_RS18180 (3727741)	3727741..3727899	+	159	Protein_3566	integrase	-
QJB02_RS18185 (3728126)	3728126..3728461	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB02_RS18190 (3728669)	3728669..3729445	+	777	WP_000171155.1	site-specific integrase	-
QJB02_RS18195 (3729610)	3729610..3730530	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB02_RS18200 (3730517)	3730517..3731299	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB02_RS18205 (3731583)	3731583..3734681	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3689397..3738362	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280707 WP_000365807.1 NZ_CP124508:c3730530-3729610 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280707 WP_001295795.1 NZ_CP124508:c3731299-3730517 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0