Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3546321..3546939 Replicon chromosome
Accession NZ_CP124508
Organism Escherichia coli strain AVS0068

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB02_RS17335 Protein ID WP_001291435.1
Coordinates 3546721..3546939 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB02_RS17330 Protein ID WP_000344800.1
Coordinates 3546321..3546695 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB02_RS17320 (3541410) 3541410..3542603 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJB02_RS17325 (3542626) 3542626..3545775 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB02_RS17330 (3546321) 3546321..3546695 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB02_RS17335 (3546721) 3546721..3546939 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB02_RS17340 (3547112) 3547112..3547663 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJB02_RS17345 (3547779) 3547779..3548249 + 471 WP_000136192.1 YlaC family protein -
QJB02_RS17350 (3548413) 3548413..3549963 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB02_RS17355 (3550005) 3550005..3550358 - 354 WP_000878147.1 DUF1428 family protein -
QJB02_RS17365 (3550737) 3550737..3551048 + 312 WP_000409908.1 MGMT family protein -
QJB02_RS17370 (3551079) 3551079..3551651 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280706 WP_001291435.1 NZ_CP124508:3546721-3546939 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280706 WP_000344800.1 NZ_CP124508:3546321-3546695 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References