Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2878295..2878766 Replicon chromosome
Accession NZ_CP124508
Organism Escherichia coli strain AVS0068

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJB02_RS14125 Protein ID WP_001303511.1
Coordinates 2878488..2878766 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJB02_RS14120 Protein ID WP_001302048.1
Coordinates 2878295..2878486 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB02_RS14050 (2873362) 2873362..2873529 - 168 WP_000207997.1 hypothetical protein -
QJB02_RS14055 (2873540) 2873540..2873803 - 264 WP_000224216.1 hypothetical protein -
QJB02_RS14060 (2873805) 2873805..2874023 - 219 WP_001142588.1 DUF4014 family protein -
QJB02_RS14065 (2874025) 2874025..2874240 - 216 WP_000510387.1 hypothetical protein -
QJB02_RS14070 (2874241) 2874241..2874600 - 360 WP_001289986.1 hypothetical protein -
QJB02_RS14075 (2874597) 2874597..2874773 - 177 WP_021534704.1 hypothetical protein -
QJB02_RS14080 (2874766) 2874766..2874948 - 183 WP_001224665.1 hypothetical protein -
QJB02_RS14085 (2875077) 2875077..2875388 - 312 WP_021534703.1 hypothetical protein -
QJB02_RS14090 (2875381) 2875381..2875635 - 255 WP_000004322.1 hypothetical protein -
QJB02_RS14095 (2875632) 2875632..2876054 - 423 WP_021534702.1 DUF977 family protein -
QJB02_RS14100 (2876095) 2876095..2877057 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJB02_RS14105 (2877080) 2877080..2877505 - 426 WP_000693943.1 toxin YdaT family protein -
QJB02_RS14110 (2877502) 2877502..2877804 - 303 WP_000172738.1 transcriptional regulator -
QJB02_RS14115 (2877903) 2877903..2878274 + 372 WP_001169687.1 hypothetical protein -
QJB02_RS14120 (2878295) 2878295..2878486 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJB02_RS14125 (2878488) 2878488..2878766 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJB02_RS14130 (2879058) 2879058..2879210 + 153 WP_000380313.1 DUF1391 family protein -
QJB02_RS14135 (2879222) 2879222..2879560 + 339 WP_000394541.1 hypothetical protein -
QJB02_RS14140 (2879549) 2879549..2879743 - 195 WP_001295058.1 hypothetical protein -
QJB02_RS14145 (2880310) 2880310..2880498 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJB02_RS14150 (2880495) 2880495..2880683 + 189 WP_000199480.1 DUF1482 family protein -
QJB02_RS14155 (2880779) 2880779..2883250 + 2472 WP_032284123.1 exonuclease -
QJB02_RS14160 (2883312) 2883312..2883581 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD - 2771958..2889862 117904


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280704 WP_001303511.1 NZ_CP124508:2878488-2878766 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280704 WP_001302048.1 NZ_CP124508:2878295-2878486 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References