Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4110178..4110754 Replicon chromosome
Accession NZ_CP124506
Organism Escherichia coli strain AVS0750

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP88_RS20135 Protein ID WP_001297643.1
Coordinates 4110467..4110754 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP88_RS20130 Protein ID WP_000063156.1
Coordinates 4110178..4110480 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP88_RS20115 (4106774) 4106774..4108924 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP88_RS20120 (4108974) 4108974..4109177 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP88_RS20125 (4109188) 4109188..4110144 + 957 WP_001297640.1 GTPase -
QJP88_RS20130 (4110178) 4110178..4110480 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP88_RS20135 (4110467) 4110467..4110754 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP88_RS20140 (4110953) 4110953..4111650 - 698 Protein_3952 IS1 family transposase -
QJP88_RS20145 (4111707) 4111707..4111802 + 96 Protein_3953 dienelactone hydrolase family protein -
QJP88_RS20150 (4111948) 4111948..4113180 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP88_RS20155 (4113221) 4113221..4114501 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280687 WP_001297643.1 NZ_CP124506:c4110754-4110467 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280687 WP_000063156.1 NZ_CP124506:c4110480-4110178 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References