Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4000703..4001253 | Replicon | chromosome |
Accession | NZ_CP124506 | ||
Organism | Escherichia coli strain AVS0750 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | QJP88_RS19605 | Protein ID | WP_001160966.1 |
Coordinates | 4000703..4001017 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | QJP88_RS19610 | Protein ID | WP_000125566.1 |
Coordinates | 4001020..4001253 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QJP88_RS19580 (3996378) | 3996378..3997664 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
QJP88_RS19585 (3997664) | 3997664..3998653 | + | 990 | WP_000241227.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
QJP88_RS19590 (3998650) | 3998650..3999471 | + | 822 | WP_001065363.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
QJP88_RS19595 (3999474) | 3999474..3999851 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
QJP88_RS19600 (3999858) | 3999858..4000706 | + | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
QJP88_RS19605 (4000703) | 4000703..4001017 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
QJP88_RS19610 (4001020) | 4001020..4001253 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
QJP88_RS19615 (4001339) | 4001339..4001818 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
QJP88_RS19620 (4002010) | 4002010..4003872 | - | 1863 | WP_000377124.1 | glutathione-regulated potassium-efflux system protein KefC | - |
QJP88_RS19625 (4003865) | 4003865..4004395 | - | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
QJP88_RS19630 (4004503) | 4004503..4005834 | - | 1332 | WP_001183207.1 | MFS transporter | - |
QJP88_RS19635 (4005893) | 4005893..4006180 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T280686 WP_001160966.1 NZ_CP124506:c4001017-4000703 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |