Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4000703..4001253 Replicon chromosome
Accession NZ_CP124506
Organism Escherichia coli strain AVS0750

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag QJP88_RS19605 Protein ID WP_001160966.1
Coordinates 4000703..4001017 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJP88_RS19610 Protein ID WP_000125566.1
Coordinates 4001020..4001253 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP88_RS19580 (3996378) 3996378..3997664 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QJP88_RS19585 (3997664) 3997664..3998653 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJP88_RS19590 (3998650) 3998650..3999471 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJP88_RS19595 (3999474) 3999474..3999851 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJP88_RS19600 (3999858) 3999858..4000706 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJP88_RS19605 (4000703) 4000703..4001017 - 315 WP_001160966.1 CcdB family protein Toxin
QJP88_RS19610 (4001020) 4001020..4001253 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJP88_RS19615 (4001339) 4001339..4001818 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJP88_RS19620 (4002010) 4002010..4003872 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
QJP88_RS19625 (4003865) 4003865..4004395 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJP88_RS19630 (4004503) 4004503..4005834 - 1332 WP_001183207.1 MFS transporter -
QJP88_RS19635 (4005893) 4005893..4006180 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-103)

Antitoxin

(8-77)


Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T280686 WP_001160966.1 NZ_CP124506:c4001017-4000703 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp


Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT280686 WP_000125566.1 NZ_CP124506:c4001253-4001020 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829G815


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References