Detailed information of TA system TA280685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3771170..3772859
• Replicon: chromosome
• Accession: NZ_CP124506
• Organism: Escherichia coli strain AVS0750

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP88_RS18530
• Protein ID: WP_000365807.1
• Coordinates: 3771170..3772090 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP88_RS18535
• Protein ID: WP_001295795.1
• Coordinates: 3772077..3772859 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP88_RS18490 (3766643)	3766643..3767353	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP88_RS18495 (3767660)	3767660..3767989	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP88_RS18500 (3768001)	3768001..3768167	-	167	Protein_3633	tail fiber assembly protein	-
QJP88_RS18505 (3768238)	3768238..3768852	-	615	WP_001019923.1	YagU family protein	-
QJP88_RS18510 (3769067)	3769067..3769252	-	186	WP_000146240.1	hypothetical protein	-
QJP88_RS18515 (3769301)	3769301..3769459	+	159	Protein_3636	integrase	-
QJP88_RS18520 (3769686)	3769686..3770021	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP88_RS18525 (3770229)	3770229..3771005	+	777	WP_000171155.1	site-specific integrase	-
QJP88_RS18530 (3771170)	3771170..3772090	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP88_RS18535 (3772077)	3772077..3772859	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP88_RS18540 (3773143)	3773143..3776241	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3730957..3779922	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280685 WP_000365807.1 NZ_CP124506:c3772090-3771170 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280685 WP_001295795.1 NZ_CP124506:c3772859-3772077 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0