Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2919856..2920327 Replicon chromosome
Accession NZ_CP124506
Organism Escherichia coli strain AVS0750

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP88_RS14460 Protein ID WP_001303511.1
Coordinates 2920049..2920327 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP88_RS14455 Protein ID WP_001302048.1
Coordinates 2919856..2920047 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP88_RS14385 (2914923) 2914923..2915090 - 168 WP_000207997.1 hypothetical protein -
QJP88_RS14390 (2915101) 2915101..2915364 - 264 WP_000224216.1 hypothetical protein -
QJP88_RS14395 (2915366) 2915366..2915584 - 219 WP_001142588.1 DUF4014 family protein -
QJP88_RS14400 (2915586) 2915586..2915801 - 216 WP_000510387.1 hypothetical protein -
QJP88_RS14405 (2915802) 2915802..2916161 - 360 WP_001289986.1 hypothetical protein -
QJP88_RS14410 (2916158) 2916158..2916334 - 177 WP_021534704.1 hypothetical protein -
QJP88_RS14415 (2916327) 2916327..2916509 - 183 WP_001224665.1 hypothetical protein -
QJP88_RS14420 (2916638) 2916638..2916949 - 312 WP_021534703.1 hypothetical protein -
QJP88_RS14425 (2916942) 2916942..2917196 - 255 WP_000004322.1 hypothetical protein -
QJP88_RS14430 (2917193) 2917193..2917615 - 423 WP_021534702.1 DUF977 family protein -
QJP88_RS14435 (2917656) 2917656..2918618 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP88_RS14440 (2918641) 2918641..2919066 - 426 WP_000693943.1 toxin YdaT family protein -
QJP88_RS14445 (2919063) 2919063..2919365 - 303 WP_000172738.1 transcriptional regulator -
QJP88_RS14450 (2919464) 2919464..2919835 + 372 WP_001169687.1 hypothetical protein -
QJP88_RS14455 (2919856) 2919856..2920047 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP88_RS14460 (2920049) 2920049..2920327 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP88_RS14465 (2920619) 2920619..2920771 + 153 WP_000380313.1 DUF1391 family protein -
QJP88_RS14470 (2920783) 2920783..2921121 + 339 WP_000394541.1 hypothetical protein -
QJP88_RS14475 (2921110) 2921110..2921304 - 195 WP_001295058.1 hypothetical protein -
QJP88_RS14480 (2921871) 2921871..2922059 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP88_RS14485 (2922056) 2922056..2922244 + 189 WP_000199480.1 DUF1482 family protein -
QJP88_RS14490 (2922340) 2922340..2924811 + 2472 WP_032284123.1 exonuclease -
QJP88_RS14495 (2924873) 2924873..2925142 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2901629..2929537 27908
- inside Prophage sitABCD - 2784776..2933397 148621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280682 WP_001303511.1 NZ_CP124506:2920049-2920327 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280682 WP_001302048.1 NZ_CP124506:2919856-2920047 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References