Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4786969..4787769 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP73_RS23230 Protein ID WP_000342452.1
Coordinates 4786969..4787496 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP73_RS23235 Protein ID WP_001277107.1
Coordinates 4787503..4787769 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS23205 (4782045) 4782045..4782812 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP73_RS23210 (4782809) 4782809..4784086 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP73_RS23215 (4784083) 4784083..4785009 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP73_RS23220 (4785057) 4785057..4786166 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP73_RS23225 (4786589) 4786589..4786972 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP73_RS23230 (4786969) 4786969..4787496 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP73_RS23235 (4787503) 4787503..4787769 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP73_RS23240 (4787918) 4787918..4789021 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP73_RS23245 (4789292) 4789292..4790146 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP73_RS23250 (4790391) 4790391..4791449 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
QJP73_RS23255 (4791442) 4791442..4792110 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280667 WP_000342452.1 NZ_CP124502:c4787496-4786969 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280667 WP_001277107.1 NZ_CP124502:c4787769-4787503 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References