Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4102339..4102993 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP73_RS19770 Protein ID WP_000244765.1
Coordinates 4102339..4102746 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP73_RS19775 Protein ID WP_000354050.1
Coordinates 4102727..4102993 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS19750 (4098296) 4098296..4100029 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP73_RS19755 (4100035) 4100035..4100745 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP73_RS19760 (4100770) 4100770..4101666 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP73_RS19765 (4101778) 4101778..4102299 + 522 WP_001055874.1 flavodoxin FldB -
QJP73_RS19770 (4102339) 4102339..4102746 - 408 WP_000244765.1 protein YgfX Toxin
QJP73_RS19775 (4102727) 4102727..4102993 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP73_RS19780 (4103236) 4103236..4104216 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJP73_RS19785 (4104293) 4104293..4104952 - 660 WP_000250275.1 hemolysin III family protein -
QJP73_RS19790 (4105116) 4105116..4105427 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP73_RS19795 (4105472) 4105472..4106905 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280663 WP_000244765.1 NZ_CP124502:c4102746-4102339 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280663 WP_000354050.1 NZ_CP124502:c4102993-4102727 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References