28066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710785..711410 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag RVBD_RS03235 Protein ID WP_003403218.1
Coordinates 711009..711410 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag RVBD_RS03230 Protein ID WP_003403213.1
Coordinates 710785..711012 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS03200 705964..706185 - 222 WP_003898525.1 DUF4926 domain-containing protein -
RVBD_RS03205 706327..706932 + 606 WP_003898526.1 hypothetical protein -
RVBD_RS03210 706951..709518 - 2568 WP_003900188.1 SEC-C domain-containing protein -
RVBD_RS03215 709602..710351 + 750 WP_003898528.1 hypothetical protein -
RVBD_RS03220 710348..710590 + 243 WP_003403210.1 hypothetical protein -
RVBD_RS03230 710785..711012 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
RVBD_RS03235 711009..711410 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
RVBD_RS22380 711539..712234 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
RVBD_RS22385 712231..712722 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
RVBD_RS03245 712719..713810 + 1092 WP_003906403.1 galactokinase -
RVBD_RS03255 714205..715269 + 1065 WP_003898532.1 hypothetical protein -
RVBD_RS03260 715373..716320 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T28066 WP_003403218.1 NC_018143:711009-711410 [Mycobacterium tuberculosis H37Rv]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T28066 NC_018143:711009-711410 [Mycobacterium tuberculosis H37Rv]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT28066 WP_003403213.1 NC_018143:710785-711012 [Mycobacterium tuberculosis H37Rv]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT28066 NC_018143:710785-711012 [Mycobacterium tuberculosis H37Rv]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References