Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2124143..2124614 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP73_RS10055 Protein ID WP_001303511.1
Coordinates 2124143..2124421 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP73_RS10060 Protein ID WP_001302048.1
Coordinates 2124423..2124614 (-) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS10020 (2119328) 2119328..2119597 - 270 WP_000003742.1 excisionase -
QJP73_RS10025 (2119659) 2119659..2122130 - 2472 WP_032284123.1 exonuclease -
QJP73_RS10030 (2122226) 2122226..2122414 - 189 WP_000199480.1 DUF1482 family protein -
QJP73_RS10035 (2122411) 2122411..2122599 - 189 WP_000449172.1 cell division inhibition protein DicB -
QJP73_RS10040 (2123166) 2123166..2123360 + 195 WP_001295058.1 hypothetical protein -
QJP73_RS10045 (2123349) 2123349..2123687 - 339 WP_000394541.1 hypothetical protein -
QJP73_RS10050 (2123699) 2123699..2123851 - 153 WP_000380313.1 DUF1391 family protein -
QJP73_RS10055 (2124143) 2124143..2124421 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP73_RS10060 (2124423) 2124423..2124614 - 192 WP_001302048.1 hypothetical protein Antitoxin
QJP73_RS10065 (2124635) 2124635..2125006 - 372 WP_001169687.1 hypothetical protein -
QJP73_RS10070 (2125105) 2125105..2125407 + 303 WP_000172738.1 transcriptional regulator -
QJP73_RS10075 (2125404) 2125404..2125829 + 426 WP_000693943.1 toxin YdaT family protein -
QJP73_RS10080 (2125852) 2125852..2126814 + 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP73_RS10085 (2126855) 2126855..2127277 + 423 WP_021534702.1 DUF977 family protein -
QJP73_RS10090 (2127274) 2127274..2127528 + 255 WP_000004322.1 hypothetical protein -
QJP73_RS10095 (2127521) 2127521..2127832 + 312 WP_021534703.1 hypothetical protein -
QJP73_RS10100 (2127961) 2127961..2128143 + 183 WP_001224665.1 hypothetical protein -
QJP73_RS10105 (2128136) 2128136..2128312 + 177 WP_021534704.1 hypothetical protein -
QJP73_RS10110 (2128309) 2128309..2128668 + 360 WP_001289986.1 hypothetical protein -
QJP73_RS10115 (2128669) 2128669..2128884 + 216 WP_000510387.1 hypothetical protein -
QJP73_RS10120 (2128886) 2128886..2129104 + 219 WP_001142588.1 DUF4014 family protein -
QJP73_RS10125 (2129106) 2129106..2129369 + 264 WP_000224216.1 hypothetical protein -
QJP73_RS10130 (2129380) 2129380..2129547 + 168 WP_000207997.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD - 2118241..2231849 113608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280651 WP_001303511.1 NZ_CP124502:c2124421-2124143 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280651 WP_001302048.1 NZ_CP124502:c2124614-2124423 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References