28065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703247..703890 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag RVBD_RS03180 Protein ID WP_003403187.1
Coordinates 703489..703890 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag RVBD_RS03175 Protein ID WP_003403184.1
Coordinates 703247..703492 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS03140 698527..698997 - 471 WP_003403144.1 HAMP domain-containing protein -
RVBD_RS03145 699041..699802 - 762 WP_003403148.1 two-component system response regulator TcrA -
RVBD_RS03150 699859..700170 + 312 WP_003403164.1 hypothetical protein -
RVBD_RS03155 700242..701192 + 951 WP_003900184.1 DUF1259 domain-containing protein -
RVBD_RS03160 701433..702017 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
RVBD_RS03165 702019..702729 + 711 Protein_626 transposase -
RVBD_RS03170 702732..703202 + 471 WP_003898523.1 hypothetical protein -
RVBD_RS03175 703247..703492 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RVBD_RS03180 703489..703890 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS22065 704278..704445 - 168 WP_077385191.1 DUF3800 domain-containing protein -
RVBD_RS22070 704478..704675 - 198 WP_003403191.1 hypothetical protein -
RVBD_RS03195 704755..705912 - 1158 WP_003898524.1 hypothetical protein -
RVBD_RS03200 705964..706185 - 222 WP_003898525.1 DUF4926 domain-containing protein -
RVBD_RS03205 706327..706932 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T28065 WP_003403187.1 NC_018143:703489-703890 [Mycobacterium tuberculosis H37Rv]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T28065 NC_018143:703489-703890 [Mycobacterium tuberculosis H37Rv]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT28065 WP_003403184.1 NC_018143:703247-703492 [Mycobacterium tuberculosis H37Rv]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT28065 NC_018143:703247-703492 [Mycobacterium tuberculosis H37Rv]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References