Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1456442..1457060 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP73_RS06850 Protein ID WP_001291435.1
Coordinates 1456442..1456660 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP73_RS06855 Protein ID WP_000344800.1
Coordinates 1456686..1457060 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS06815 (1451730) 1451730..1452302 + 573 WP_000779841.1 YbaY family lipoprotein -
QJP73_RS06820 (1452333) 1452333..1452644 - 312 WP_000409908.1 MGMT family protein -
QJP73_RS06830 (1453023) 1453023..1453376 + 354 WP_000878147.1 DUF1428 family protein -
QJP73_RS06835 (1453418) 1453418..1454968 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP73_RS06840 (1455132) 1455132..1455602 - 471 WP_000136192.1 YlaC family protein -
QJP73_RS06845 (1455718) 1455718..1456269 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP73_RS06850 (1456442) 1456442..1456660 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP73_RS06855 (1456686) 1456686..1457060 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP73_RS06860 (1457606) 1457606..1460755 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP73_RS06865 (1460778) 1460778..1461971 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280649 WP_001291435.1 NZ_CP124502:c1456660-1456442 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280649 WP_000344800.1 NZ_CP124502:c1457060-1456686 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References