Detailed information of TA system TA280648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1272082..1273771
• Replicon: chromosome
• Accession: NZ_CP124502
• Organism: Escherichia coli strain AVS0970

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP73_RS05990
• Protein ID: WP_000365807.1
• Coordinates: 1272851..1273771 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP73_RS05985
• Protein ID: WP_001295795.1
• Coordinates: 1272082..1272864 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP73_RS05980 (1268700)	1268700..1271798	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP73_RS05985 (1272082)	1272082..1272864	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP73_RS05990 (1272851)	1272851..1273771	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP73_RS05995 (1273936)	1273936..1274712	-	777	WP_000171155.1	site-specific integrase	-
QJP73_RS06000 (1274920)	1274920..1275255	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP73_RS06005 (1275482)	1275482..1275640	-	159	Protein_1159	integrase	-
QJP73_RS06010 (1275689)	1275689..1275874	+	186	WP_000146240.1	hypothetical protein	-
QJP73_RS06015 (1276089)	1276089..1276703	+	615	WP_001019923.1	YagU family protein	-
QJP73_RS06020 (1276774)	1276774..1276940	+	167	Protein_1162	tail fiber assembly protein	-
QJP73_RS06025 (1276952)	1276952..1277281	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP73_RS06030 (1277588)	1277588..1278298	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1265019..1313984	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280648 WP_000365807.1 NZ_CP124502:1272851-1273771 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280648 WP_001295795.1 NZ_CP124502:1272082-1272864 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0