Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 862839..863673 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1J6XFW9
Locus tag QJP73_RS04005 Protein ID WP_000854770.1
Coordinates 863296..863673 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1N885
Locus tag QJP73_RS04000 Protein ID WP_001280950.1
Coordinates 862839..863207 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS03970 (857992) 857992..859892 + 1901 Protein_763 Ag43/Cah family autotransporter adhesin -
QJP73_RS03975 (859963) 859963..860158 + 196 Protein_764 DUF905 family protein -
QJP73_RS03980 (860276) 860276..861094 + 819 WP_001234712.1 DUF932 domain-containing protein -
QJP73_RS03985 (861436) 861436..861900 + 465 WP_000855061.1 antirestriction protein -
QJP73_RS03990 (861916) 861916..862392 + 477 WP_001186779.1 RadC family protein -
QJP73_RS03995 (862455) 862455..862676 + 222 WP_001220314.1 DUF987 domain-containing protein -
QJP73_RS04000 (862839) 862839..863207 + 369 WP_001280950.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP73_RS04005 (863296) 863296..863673 + 378 WP_000854770.1 TA system toxin CbtA family protein Toxin
QJP73_RS04010 (863670) 863670..864158 + 489 WP_000761690.1 DUF5983 family protein -
QJP73_RS04015 (864175) 864175..864351 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP73_RS04020 (864457) 864457..864606 + 150 Protein_773 hypothetical protein -
QJP73_RS04025 (864973) 864973..865278 + 306 Protein_774 helix-turn-helix domain-containing protein -
QJP73_RS04030 (865940) 865940..867562 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 814983..875319 60336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14196.37 Da        Isoelectric Point: 8.7438

>T280645 WP_000854770.1 NZ_CP124502:863296-863673 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13737.56 Da        Isoelectric Point: 7.0268

>AT280645 WP_001280950.1 NZ_CP124502:862839-863207 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6XFW9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1N885

References