Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4097128..4097704 Replicon chromosome
Accession NZ_CP124500
Organism Escherichia coli strain AVS0744

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJB04_RS19920 Protein ID WP_001297643.1
Coordinates 4097417..4097704 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJB04_RS19915 Protein ID WP_000063156.1
Coordinates 4097128..4097430 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB04_RS19900 (4093724) 4093724..4095874 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJB04_RS19905 (4095924) 4095924..4096127 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJB04_RS19910 (4096138) 4096138..4097094 + 957 WP_001297640.1 GTPase -
QJB04_RS19915 (4097128) 4097128..4097430 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJB04_RS19920 (4097417) 4097417..4097704 - 288 WP_001297643.1 BrnT family toxin Toxin
QJB04_RS19925 (4097903) 4097903..4098600 - 698 Protein_3908 IS1 family transposase -
QJB04_RS19930 (4098657) 4098657..4098752 + 96 Protein_3909 dienelactone hydrolase family protein -
QJB04_RS19935 (4098898) 4098898..4100130 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJB04_RS19940 (4100171) 4100171..4101451 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280640 WP_001297643.1 NZ_CP124500:c4097704-4097417 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280640 WP_000063156.1 NZ_CP124500:c4097430-4097128 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References