Detailed information of TA system TA280638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3758120..3759809
• Replicon: chromosome
• Accession: NZ_CP124500
• Organism: Escherichia coli strain AVS0744

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB04_RS18315
• Protein ID: WP_000365807.1
• Coordinates: 3758120..3759040 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB04_RS18320
• Protein ID: WP_001295795.1
• Coordinates: 3759027..3759809 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB04_RS18275 (3753593)	3753593..3754303	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJB04_RS18280 (3754610)	3754610..3754939	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB04_RS18285 (3754951)	3754951..3755117	-	167	Protein_3589	tail fiber assembly protein	-
QJB04_RS18290 (3755188)	3755188..3755802	-	615	WP_001019923.1	YagU family protein	-
QJB04_RS18295 (3756017)	3756017..3756202	-	186	WP_000146240.1	hypothetical protein	-
QJB04_RS18300 (3756251)	3756251..3756409	+	159	Protein_3592	integrase	-
QJB04_RS18305 (3756636)	3756636..3756971	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB04_RS18310 (3757179)	3757179..3757955	+	777	WP_000171155.1	site-specific integrase	-
QJB04_RS18315 (3758120)	3758120..3759040	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB04_RS18320 (3759027)	3759027..3759809	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB04_RS18325 (3760093)	3760093..3763191	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3717907..3766872	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280638 WP_000365807.1 NZ_CP124500:c3759040-3758120 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280638 WP_001295795.1 NZ_CP124500:c3759809-3759027 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0