Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3574831..3575449 Replicon chromosome
Accession NZ_CP124500
Organism Escherichia coli strain AVS0744

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB04_RS17455 Protein ID WP_001291435.1
Coordinates 3575231..3575449 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB04_RS17450 Protein ID WP_000344800.1
Coordinates 3574831..3575205 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB04_RS17440 (3569920) 3569920..3571113 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJB04_RS17445 (3571136) 3571136..3574285 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB04_RS17450 (3574831) 3574831..3575205 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB04_RS17455 (3575231) 3575231..3575449 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB04_RS17460 (3575622) 3575622..3576173 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJB04_RS17465 (3576289) 3576289..3576759 + 471 WP_000136192.1 YlaC family protein -
QJB04_RS17470 (3576923) 3576923..3578473 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB04_RS17475 (3578515) 3578515..3578868 - 354 WP_000878147.1 DUF1428 family protein -
QJB04_RS17485 (3579247) 3579247..3579558 + 312 WP_000409908.1 MGMT family protein -
QJB04_RS17490 (3579589) 3579589..3580161 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280637 WP_001291435.1 NZ_CP124500:3575231-3575449 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280637 WP_000344800.1 NZ_CP124500:3574831-3575205 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References