Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1009512..1010166 Replicon chromosome
Accession NZ_CP124500
Organism Escherichia coli strain AVS0744

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJB04_RS04960 Protein ID WP_000244765.1
Coordinates 1009759..1010166 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJB04_RS04955 Protein ID WP_000354050.1
Coordinates 1009512..1009778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB04_RS04935 (1005600) 1005600..1007033 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJB04_RS04940 (1007078) 1007078..1007389 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJB04_RS04945 (1007553) 1007553..1008212 + 660 WP_000250275.1 hemolysin III family protein -
QJB04_RS04950 (1008289) 1008289..1009269 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJB04_RS04955 (1009512) 1009512..1009778 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJB04_RS04960 (1009759) 1009759..1010166 + 408 WP_000244765.1 protein YgfX Toxin
QJB04_RS04965 (1010206) 1010206..1010727 - 522 WP_001055874.1 flavodoxin FldB -
QJB04_RS04970 (1010839) 1010839..1011735 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJB04_RS04975 (1011760) 1011760..1012470 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJB04_RS04980 (1012476) 1012476..1014209 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280628 WP_000244765.1 NZ_CP124500:1009759-1010166 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280628 WP_000354050.1 NZ_CP124500:1009512-1009778 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References