Detailed information of TA system TA280617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3802424..3804113
• Replicon: chromosome
• Accession: NZ_CP124498
• Organism: Escherichia coli strain AVS0655

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP65_RS18650
• Protein ID: WP_000365807.1
• Coordinates: 3802424..3803344 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP65_RS18655
• Protein ID: WP_001295795.1
• Coordinates: 3803331..3804113 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP65_RS18610 (3797897)	3797897..3798607	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP65_RS18615 (3798914)	3798914..3799243	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP65_RS18620 (3799255)	3799255..3799421	-	167	Protein_3657	tail fiber assembly protein	-
QJP65_RS18625 (3799492)	3799492..3800106	-	615	WP_001019923.1	YagU family protein	-
QJP65_RS18630 (3800321)	3800321..3800506	-	186	WP_000146240.1	hypothetical protein	-
QJP65_RS18635 (3800555)	3800555..3800713	+	159	Protein_3660	integrase	-
QJP65_RS18640 (3800940)	3800940..3801275	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP65_RS18645 (3801483)	3801483..3802259	+	777	WP_000171155.1	site-specific integrase	-
QJP65_RS18650 (3802424)	3802424..3803344	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP65_RS18655 (3803331)	3803331..3804113	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP65_RS18660 (3804397)	3804397..3807495	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3762211..3811176	48965
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3763251..3811176	47925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280617 WP_000365807.1 NZ_CP124498:c3803344-3802424 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280617 WP_001295795.1 NZ_CP124498:c3804113-3803331 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0