Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 358818..359618 Replicon chromosome
Accession NZ_CP124498
Organism Escherichia coli strain AVS0655

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP65_RS01670 Protein ID WP_000342452.1
Coordinates 359091..359618 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP65_RS01665 Protein ID WP_001277107.1
Coordinates 358818..359084 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP65_RS01645 (354477) 354477..355145 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJP65_RS01650 (355138) 355138..356196 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QJP65_RS01655 (356441) 356441..357295 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP65_RS01660 (357566) 357566..358669 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP65_RS01665 (358818) 358818..359084 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP65_RS01670 (359091) 359091..359618 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP65_RS01675 (359615) 359615..359998 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP65_RS01680 (360421) 360421..361530 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP65_RS01685 (361578) 361578..362504 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP65_RS01690 (362501) 362501..363778 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP65_RS01695 (363775) 363775..364542 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280603 WP_000342452.1 NZ_CP124498:359091-359618 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280603 WP_001277107.1 NZ_CP124498:358818-359084 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References