Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1770..2317 Replicon plasmid pAVS0662-B
Accession NZ_CP124497
Organism Escherichia coli strain AVS0662

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QJP57_RS24525 Protein ID WP_244493824.1
Coordinates 2039..2317 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6G9U792
Locus tag QJP57_RS24520 Protein ID WP_000079935.1
Coordinates 1770..2039 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP57_RS24515 (1) 1..858 + 858 WP_052972859.1 incFII family plasmid replication initiator RepA -
QJP57_RS24520 (1770) 1770..2039 + 270 WP_000079935.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QJP57_RS24525 (2039) 2039..2317 + 279 WP_244493824.1 type II toxin-antitoxin system toxin YacB Toxin
QJP57_RS24530 (2363) 2363..3211 + 849 WP_001058003.1 3'-5' exonuclease -
QJP57_RS24535 (3328) 3328..3810 + 483 WP_001311056.1 hypothetical protein -
QJP57_RS24540 (4170) 4170..5286 - 1117 Protein_5 IS91 family transposase -
QJP57_RS24545 (5286) 5286..5651 - 366 WP_000124093.1 hypothetical protein -
QJP57_RS24550 (6179) 6179..6688 + 510 WP_000115002.1 peptide deformylase -
QJP57_RS24555 (6703) 6703..6804 + 102 Protein_8 methionyl-tRNA formyltransferase -
QJP57_RS24560 (7001) 7001..7192 + 192 WP_000175572.1 DUF2164 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..75820 75820
- flank IS/Tn - - 4201..4923 722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10729.37 Da        Isoelectric Point: 8.4615

>T280600 WP_244493824.1 NZ_CP124497:2039-2317 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLAGLPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10198.53 Da        Isoelectric Point: 8.8735

>AT280600 WP_000079935.1 NZ_CP124497:1770-2039 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9U792

References