Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4114316..4114892 Replicon chromosome
Accession NZ_CP124495
Organism Escherichia coli strain AVS0662

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP57_RS20155 Protein ID WP_001297643.1
Coordinates 4114605..4114892 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP57_RS20150 Protein ID WP_000063156.1
Coordinates 4114316..4114618 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP57_RS20135 (4110912) 4110912..4113062 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP57_RS20140 (4113112) 4113112..4113315 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP57_RS20145 (4113326) 4113326..4114282 + 957 WP_001297640.1 GTPase -
QJP57_RS20150 (4114316) 4114316..4114618 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP57_RS20155 (4114605) 4114605..4114892 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP57_RS20160 (4115091) 4115091..4115788 - 698 Protein_3959 IS1 family transposase -
QJP57_RS20165 (4115845) 4115845..4115940 + 96 Protein_3960 dienelactone hydrolase family protein -
QJP57_RS20170 (4116086) 4116086..4117318 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP57_RS20175 (4117359) 4117359..4118639 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280593 WP_001297643.1 NZ_CP124495:c4114892-4114605 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280593 WP_000063156.1 NZ_CP124495:c4114618-4114316 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References