Detailed information of TA system TA280591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3737736..3739425
• Replicon: chromosome
• Accession: NZ_CP124495
• Organism: Escherichia coli strain AVS0662

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP57_RS18285
• Protein ID: WP_000365807.1
• Coordinates: 3737736..3738656 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP57_RS18290
• Protein ID: WP_001295795.1
• Coordinates: 3738643..3739425 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP57_RS18245 (3733209)	3733209..3733919	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP57_RS18250 (3734226)	3734226..3734555	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP57_RS18255 (3734567)	3734567..3734733	-	167	Protein_3587	tail fiber assembly protein	-
QJP57_RS18260 (3734804)	3734804..3735418	-	615	WP_001019923.1	YagU family protein	-
QJP57_RS18265 (3735633)	3735633..3735818	-	186	WP_000146240.1	hypothetical protein	-
QJP57_RS18270 (3735867)	3735867..3736025	+	159	Protein_3590	integrase	-
QJP57_RS18275 (3736252)	3736252..3736587	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP57_RS18280 (3736795)	3736795..3737571	+	777	WP_000171155.1	site-specific integrase	-
QJP57_RS18285 (3737736)	3737736..3738656	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP57_RS18290 (3738643)	3738643..3739425	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP57_RS18295 (3739709)	3739709..3742807	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3721509..3746488	24979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280591 WP_000365807.1 NZ_CP124495:c3738656-3737736 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280591 WP_001295795.1 NZ_CP124495:c3739425-3738643 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0