Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3610353..3610971 Replicon chromosome
Accession NZ_CP124495
Organism Escherichia coli strain AVS0662

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP57_RS17640 Protein ID WP_001291435.1
Coordinates 3610753..3610971 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP57_RS17635 Protein ID WP_000344800.1
Coordinates 3610353..3610727 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP57_RS17625 (3605442) 3605442..3606635 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP57_RS17630 (3606658) 3606658..3609807 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP57_RS17635 (3610353) 3610353..3610727 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP57_RS17640 (3610753) 3610753..3610971 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP57_RS17645 (3611144) 3611144..3611695 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP57_RS17650 (3611811) 3611811..3612281 + 471 WP_000136192.1 YlaC family protein -
QJP57_RS17655 (3612445) 3612445..3613995 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP57_RS17660 (3614037) 3614037..3614390 - 354 WP_000878147.1 DUF1428 family protein -
QJP57_RS17670 (3614769) 3614769..3615080 + 312 WP_000409908.1 MGMT family protein -
QJP57_RS17675 (3615111) 3615111..3615683 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280590 WP_001291435.1 NZ_CP124495:3610753-3610971 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280590 WP_000344800.1 NZ_CP124495:3610353-3610727 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References