280588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2939144..2939615 Replicon chromosome
Accession NZ_CP124495
Organism Escherichia coli strain AVS0662

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP57_RS14410 Protein ID WP_001303511.1
Coordinates 2939337..2939615 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP57_RS14405 Protein ID WP_001302048.1
Coordinates 2939144..2939335 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP57_RS14360 (2934393) 2934393..2934611 - 219 WP_001610644.1 DUF4014 family protein -
QJP57_RS14365 (2934644) 2934644..2934856 - 213 WP_000072553.1 hypothetical protein -
QJP57_RS14370 (2934962) 2934962..2935384 - 423 Protein_2829 DUF977 family protein -
QJP57_RS14375 (2935400) 2935400..2936170 - 771 WP_000450998.1 DUF1627 domain-containing protein -
QJP57_RS14380 (2936192) 2936192..2936938 - 747 WP_000788950.1 ATP-binding protein -
QJP57_RS14385 (2936945) 2936945..2937907 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP57_RS14390 (2937930) 2937930..2938355 - 426 WP_000693943.1 toxin YdaT family protein -
QJP57_RS14395 (2938352) 2938352..2938654 - 303 WP_001556930.1 transcriptional regulator -
QJP57_RS14400 (2938752) 2938752..2939123 + 372 WP_001169687.1 hypothetical protein -
QJP57_RS14405 (2939144) 2939144..2939335 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP57_RS14410 (2939337) 2939337..2939615 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP57_RS14415 (2939906) 2939906..2940058 + 153 WP_000380313.1 DUF1391 family protein -
QJP57_RS14420 (2940070) 2940070..2940408 + 339 WP_000394541.1 hypothetical protein -
QJP57_RS14425 (2940397) 2940397..2940591 - 195 WP_001295058.1 hypothetical protein -
QJP57_RS14430 (2941167) 2941167..2941355 + 189 WP_000449175.1 cell division inhibition protein DicB -
QJP57_RS14435 (2941352) 2941352..2941540 + 189 WP_000199475.1 DUF1482 family protein -
QJP57_RS14440 (2941633) 2941633..2944071 + 2439 WP_000102132.1 exonuclease -
QJP57_RS14445 (2944133) 2944133..2944402 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2921751..2948797 27046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280588 WP_001303511.1 NZ_CP124495:2939337-2939615 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280588 WP_001302048.1 NZ_CP124495:2939144-2939335 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References