Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3736695..3738384 Replicon chromosome
Accession NZ_CP124492
Organism Escherichia coli strain AVS0225

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag QJA99_RS18315 Protein ID WP_283201869.1
Coordinates 3736695..3737615 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag QJA99_RS18320 Protein ID WP_001295795.1
Coordinates 3737602..3738384 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJA99_RS18275 (3732168) 3732168..3732878 + 711 WP_001295798.1 fimbrial chaperone EcpE -
QJA99_RS18280 (3733185) 3733185..3733514 + 330 WP_001295797.1 YkgJ family cysteine cluster protein -
QJA99_RS18285 (3733526) 3733526..3733692 - 167 Protein_3587 tail fiber assembly protein -
QJA99_RS18290 (3733763) 3733763..3734377 - 615 WP_001019923.1 YagU family protein -
QJA99_RS18295 (3734592) 3734592..3734777 - 186 WP_000146240.1 hypothetical protein -
QJA99_RS18300 (3734826) 3734826..3734984 + 159 Protein_3590 integrase -
QJA99_RS18305 (3735211) 3735211..3735546 + 336 WP_000996167.1 Arm DNA-binding domain-containing protein -
QJA99_RS18310 (3735754) 3735754..3736530 + 777 WP_000171155.1 site-specific integrase -
QJA99_RS18315 (3736695) 3736695..3737615 - 921 WP_283201869.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJA99_RS18320 (3737602) 3737602..3738384 - 783 WP_001295795.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
QJA99_RS18325 (3738668) 3738668..3741766 + 3099 WP_000673070.1 type I restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3696482..3745447 48965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-223)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-90)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34569.95 Da        Isoelectric Point: 8.1217

>T280570 WP_283201869.1 NZ_CP124492:c3737615-3736695 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIKVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Download         Length: 921 bp

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29099.24 Da        Isoelectric Point: 8.5975

>AT280570 WP_001295795.1 NZ_CP124492:c3738384-3737602 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References