Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3553406..3554024 Replicon chromosome
Accession NZ_CP124492
Organism Escherichia coli strain AVS0225

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJA99_RS17455 Protein ID WP_001291435.1
Coordinates 3553806..3554024 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJA99_RS17450 Protein ID WP_000344800.1
Coordinates 3553406..3553780 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJA99_RS17440 (3548495) 3548495..3549688 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJA99_RS17445 (3549711) 3549711..3552860 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJA99_RS17450 (3553406) 3553406..3553780 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJA99_RS17455 (3553806) 3553806..3554024 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJA99_RS17460 (3554197) 3554197..3554748 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJA99_RS17465 (3554864) 3554864..3555334 + 471 WP_000136192.1 YlaC family protein -
QJA99_RS17470 (3555498) 3555498..3557048 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJA99_RS17475 (3557090) 3557090..3557443 - 354 WP_000878147.1 DUF1428 family protein -
QJA99_RS17485 (3557822) 3557822..3558133 + 312 WP_000409908.1 MGMT family protein -
QJA99_RS17490 (3558164) 3558164..3558736 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280569 WP_001291435.1 NZ_CP124492:3553806-3554024 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280569 WP_000344800.1 NZ_CP124492:3553406-3553780 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References