Detailed information of TA system TA280550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3678685..3680374
• Replicon: chromosome
• Accession: NZ_CP124490
• Organism: Escherichia coli strain AVS0456

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP91_RS17855
• Protein ID: WP_000365807.1
• Coordinates: 3678685..3679605 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP91_RS17860
• Protein ID: WP_001295795.1
• Coordinates: 3679592..3680374 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP91_RS17815 (3674158)	3674158..3674868	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP91_RS17820 (3675175)	3675175..3675504	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP91_RS17825 (3675516)	3675516..3675682	-	167	Protein_3502	tail fiber assembly protein	-
QJP91_RS17830 (3675753)	3675753..3676367	-	615	WP_001019923.1	YagU family protein	-
QJP91_RS17835 (3676582)	3676582..3676767	-	186	WP_000146240.1	hypothetical protein	-
QJP91_RS17840 (3676816)	3676816..3676974	+	159	Protein_3505	integrase	-
QJP91_RS17845 (3677201)	3677201..3677536	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP91_RS17850 (3677744)	3677744..3678520	+	777	WP_000171155.1	site-specific integrase	-
QJP91_RS17855 (3678685)	3678685..3679605	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP91_RS17860 (3679592)	3679592..3680374	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP91_RS17865 (3680658)	3680658..3683756	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3638472..3687437	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280550 WP_000365807.1 NZ_CP124490:c3679605-3678685 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280550 WP_001295795.1 NZ_CP124490:c3680374-3679592 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0