Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3495396..3496014 Replicon chromosome
Accession NZ_CP124490
Organism Escherichia coli strain AVS0456

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP91_RS16995 Protein ID WP_001291435.1
Coordinates 3495796..3496014 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP91_RS16990 Protein ID WP_000344800.1
Coordinates 3495396..3495770 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP91_RS16980 (3490485) 3490485..3491678 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP91_RS16985 (3491701) 3491701..3494850 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP91_RS16990 (3495396) 3495396..3495770 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP91_RS16995 (3495796) 3495796..3496014 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP91_RS17000 (3496187) 3496187..3496738 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP91_RS17005 (3496854) 3496854..3497324 + 471 WP_000136192.1 YlaC family protein -
QJP91_RS17010 (3497488) 3497488..3499038 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP91_RS17015 (3499080) 3499080..3499433 - 354 WP_000878147.1 DUF1428 family protein -
QJP91_RS17025 (3499812) 3499812..3500123 + 312 WP_000409908.1 MGMT family protein -
QJP91_RS17030 (3500154) 3500154..3500726 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280549 WP_001291435.1 NZ_CP124490:3495796-3496014 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280549 WP_000344800.1 NZ_CP124490:3495396-3495770 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References