280535

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 60451..61052 Replicon plasmid pAVS0542-A
Accession NZ_CP124488
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag QJP68_RS24575 Protein ID WP_001216034.1
Coordinates 60672..61052 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QJP68_RS24570 Protein ID WP_001190712.1
Coordinates 60451..60672 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS24560 (57444) 57444..58715 - 1272 WP_023142242.1 restriction endonuclease subunit S -
QJP68_RS24565 (58712) 58712..60268 - 1557 WP_001617892.1 type I restriction-modification system subunit M -
QJP68_RS24570 (60451) 60451..60672 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QJP68_RS24575 (60672) 60672..61052 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QJP68_RS24580 (61057) 61057..61236 + 180 WP_001513661.1 hypothetical protein -
QJP68_RS24585 (61264) 61264..61542 + 279 Protein_67 pdcB -
QJP68_RS24590 (61547) 61547..61960 + 414 Protein_68 integrase core domain-containing protein -
QJP68_RS24595 (61910) 61910..62245 - 336 WP_169329198.1 type I deoxyribonuclease HsdR -
QJP68_RS24600 (62455) 62455..63435 - 981 WP_000019407.1 IS5-like element IS5 family transposase -
QJP68_RS24605 (63679) 63679..65082 + 1404 WP_001373486.1 S-methylmethionine permease -
QJP68_RS24610 (65069) 65069..66001 + 933 WP_000081352.1 homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-27 - 1..69343 69343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T280535 WP_001216034.1 NZ_CP124488:60672-61052 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT280535 WP_001190712.1 NZ_CP124488:60451-60672 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References