280527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4047630..4048180 Replicon chromosome
Accession NZ_CP124487
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag QJP68_RS19870 Protein ID WP_001160966.1
Coordinates 4047630..4047944 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJP68_RS19875 Protein ID WP_000125566.1
Coordinates 4047947..4048180 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS19845 (4043305) 4043305..4044591 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QJP68_RS19850 (4044591) 4044591..4045580 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJP68_RS19855 (4045577) 4045577..4046398 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJP68_RS19860 (4046401) 4046401..4046778 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJP68_RS19865 (4046785) 4046785..4047633 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJP68_RS19870 (4047630) 4047630..4047944 - 315 WP_001160966.1 CcdB family protein Toxin
QJP68_RS19875 (4047947) 4047947..4048180 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJP68_RS19880 (4048266) 4048266..4048745 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJP68_RS19885 (4048937) 4048937..4050799 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
QJP68_RS19890 (4050792) 4050792..4051322 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJP68_RS19895 (4051430) 4051430..4052761 - 1332 WP_001183207.1 MFS transporter -
QJP68_RS19900 (4052820) 4052820..4053107 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T280527 WP_001160966.1 NZ_CP124487:c4047944-4047630 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT280527 WP_000125566.1 NZ_CP124487:c4048180-4047947 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References