Detailed information of TA system TA280526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3819170..3820859
• Replicon: chromosome
• Accession: NZ_CP124487
• Organism: Escherichia coli strain AVS0542

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP68_RS18800
• Protein ID: WP_000365807.1
• Coordinates: 3819170..3820090 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP68_RS18805
• Protein ID: WP_001295795.1
• Coordinates: 3820077..3820859 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP68_RS18760 (3814643)	3814643..3815353	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP68_RS18765 (3815660)	3815660..3815989	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP68_RS18770 (3816001)	3816001..3816167	-	167	Protein_3687	tail fiber assembly protein	-
QJP68_RS18775 (3816238)	3816238..3816852	-	615	WP_001019923.1	YagU family protein	-
QJP68_RS18780 (3817067)	3817067..3817252	-	186	WP_000146240.1	hypothetical protein	-
QJP68_RS18785 (3817301)	3817301..3817459	+	159	Protein_3690	integrase	-
QJP68_RS18790 (3817686)	3817686..3818021	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP68_RS18795 (3818229)	3818229..3819005	+	777	WP_000171155.1	site-specific integrase	-
QJP68_RS18800 (3819170)	3819170..3820090	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP68_RS18805 (3820077)	3820077..3820859	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP68_RS18810 (3821143)	3821143..3824241	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3778957..3827922	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280526 WP_000365807.1 NZ_CP124487:c3820090-3819170 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280526 WP_001295795.1 NZ_CP124487:c3820859-3820077 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0