280525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3658881..3659499 Replicon chromosome
Accession NZ_CP124487
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP68_RS18035 Protein ID WP_001291435.1
Coordinates 3659281..3659499 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP68_RS18030 Protein ID WP_000344800.1
Coordinates 3658881..3659255 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS18020 (3653970) 3653970..3655163 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP68_RS18025 (3655186) 3655186..3658335 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP68_RS18030 (3658881) 3658881..3659255 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP68_RS18035 (3659281) 3659281..3659499 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP68_RS18040 (3659672) 3659672..3660223 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP68_RS18045 (3660339) 3660339..3660809 + 471 WP_000136192.1 YlaC family protein -
QJP68_RS18050 (3660973) 3660973..3662523 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP68_RS18055 (3662565) 3662565..3662918 - 354 WP_000878147.1 DUF1428 family protein -
QJP68_RS18065 (3663297) 3663297..3663608 + 312 WP_000409908.1 MGMT family protein -
QJP68_RS18070 (3663639) 3663639..3664211 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280525 WP_001291435.1 NZ_CP124487:3659281-3659499 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280525 WP_000344800.1 NZ_CP124487:3658881-3659255 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References