280513

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 818979..820260 Replicon chromosome
Accession NZ_CP124487
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag QJP68_RS03965 Protein ID WP_001114681.1
Coordinates 818979..819872 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag QJP68_RS03970 Protein ID WP_000208383.1
Coordinates 819865..820260 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS03945 (814129) 814129..815112 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
QJP68_RS03950 (815738) 815738..816493 - 756 Protein_776 IS21-like element ISEc10 family helper ATPase IstB -
QJP68_RS03955 (816490) 816490..817989 - 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
QJP68_RS03960 (818338) 818338..818508 - 171 Protein_778 IS110 family transposase -
QJP68_RS03965 (818979) 818979..819872 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJP68_RS03970 (819865) 819865..820260 - 396 WP_000208383.1 DUF6088 family protein Antitoxin
QJP68_RS03975 (820329) 820329..821174 - 846 WP_023281696.1 DUF4942 domain-containing protein -
QJP68_RS03980 (821259) 821259..821456 - 198 WP_000839293.1 DUF957 domain-containing protein -
QJP68_RS03985 (821473) 821473..821961 - 489 WP_000761699.1 DUF5983 family protein -
QJP68_RS03990 (821958) 821958..822335 - 378 WP_000854689.1 TA system toxin CbtA family protein -
QJP68_RS03995 (822412) 822412..822792 - 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
QJP68_RS04000 (822842) 822842..823486 - 645 WP_000094916.1 hypothetical protein -
QJP68_RS04005 (823505) 823505..823726 - 222 WP_000692329.1 DUF987 domain-containing protein -
QJP68_RS04010 (823789) 823789..824265 - 477 WP_001186726.1 RadC family protein -
QJP68_RS04015 (824281) 824281..824766 - 486 WP_000849566.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T280513 WP_001114681.1 NZ_CP124487:c819872-818979 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT280513 WP_000208383.1 NZ_CP124487:c820260-819865 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References