Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2808599..2809164 Replicon chromosome
Accession NC_018142
Organism Propionibacterium propionicum F0230a

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N4CZH7
Locus tag HMPREF9154_RS12555 Protein ID WP_014847549.1
Coordinates 2808599..2808961 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3N4D1U3
Locus tag HMPREF9154_RS12560 Protein ID WP_014847550.1
Coordinates 2808958..2809164 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF9154_RS12525 2803710..2803979 + 270 WP_014847541.1 FmdB family transcriptional regulator -
HMPREF9154_RS12530 2804048..2804662 + 615 WP_014847542.1 SAF domain-containing protein -
HMPREF9154_RS12535 2804955..2805314 + 360 WP_014847544.1 large conductance mechanosensitive channel protein MscL -
HMPREF9154_RS12540 2805362..2805706 - 345 WP_014847545.1 hypothetical protein -
HMPREF9154_RS12545 2805709..2807085 - 1377 WP_041696701.1 UTP--glucose-1-phosphate uridylyltransferase -
HMPREF9154_RS12550 2807479..2808198 + 720 WP_071162217.1 hypothetical protein -
HMPREF9154_RS12555 2808599..2808961 - 363 WP_014847549.1 type II toxin-antitoxin system VapC family toxin Toxin
HMPREF9154_RS12560 2808958..2809164 - 207 WP_014847550.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HMPREF9154_RS12565 2809342..2809908 - 567 WP_014847551.1 TetR family transcriptional regulator C-terminal domain-containing protein -
HMPREF9154_RS12570 2809974..2810990 + 1017 WP_123824095.1 alpha/beta hydrolase -
HMPREF9154_RS12575 2811000..2812040 - 1041 WP_014847553.1 glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13682.99 Da        Isoelectric Point: 7.9144

>T28051 WP_014847549.1 NC_018142:c2808961-2808599 [Arachnia propionica F0230a]
VILVDTSVWIDHFRRSDLRLVRLLRGDEAGCHAMVIGELSLSSMPARTVRMSYLSNLYRFPSLHDDELLHLVETRRLWGR
GLSLVDVNLIGSVLVVPGACLWTRDKRLRAVAKELEIAFE

Download         Length: 363 bp

>T28051 NC_018142:c2808961-2808599 [Arachnia propionica F0230a]
GTGATCCTCGTCGACACCTCCGTCTGGATCGACCACTTCCGTCGCAGCGACCTGCGTCTGGTGCGCCTGCTGCGCGGAGA
CGAGGCAGGCTGCCACGCCATGGTCATCGGGGAGCTGTCGCTGAGTTCCATGCCCGCCCGCACGGTGCGGATGTCATACC
TGTCGAACCTGTACCGGTTCCCCAGCCTCCACGACGACGAACTGCTGCACCTCGTCGAGACCAGACGGTTGTGGGGTCGC
GGCCTCAGCCTGGTTGACGTCAACCTCATCGGCTCCGTCCTGGTGGTCCCGGGGGCCTGCCTGTGGACCCGCGACAAACG
TCTCCGGGCGGTCGCCAAGGAGCTGGAGATCGCCTTCGAGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7449.47 Da        Isoelectric Point: 5.0807

>AT28051 WP_014847550.1 NC_018142:c2809164-2808958 [Arachnia propionica F0230a]
MRTTVTLDDDLVARAQELTGVKERSVLLREGLETLIRVESARRLAALGGTEPEAQISSRTRDLGDLAK

Download         Length: 207 bp

>AT28051 NC_018142:c2809164-2808958 [Arachnia propionica F0230a]
ATGAGAACCACCGTTACCCTGGACGACGACTTGGTGGCACGCGCCCAGGAACTGACCGGCGTCAAGGAACGTTCCGTCCT
GCTCCGTGAGGGCCTCGAGACGCTGATTCGCGTCGAGAGCGCCCGCCGCCTGGCCGCGCTCGGCGGCACCGAACCGGAGG
CGCAGATATCGTCGCGGACCCGGGACCTCGGGGACCTCGCGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4CZH7

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D1U3

References