Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4087785..4088361 Replicon chromosome
Accession NZ_CP124483
Organism Escherichia coli strain AVS0575

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP96_RS19870 Protein ID WP_001297643.1
Coordinates 4088074..4088361 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP96_RS19865 Protein ID WP_000063156.1
Coordinates 4087785..4088087 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP96_RS19850 (4084381) 4084381..4086531 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP96_RS19855 (4086581) 4086581..4086784 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP96_RS19860 (4086795) 4086795..4087751 + 957 WP_001297640.1 GTPase -
QJP96_RS19865 (4087785) 4087785..4088087 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP96_RS19870 (4088074) 4088074..4088361 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP96_RS19875 (4088560) 4088560..4089257 - 698 Protein_3897 IS1 family transposase -
QJP96_RS19880 (4089314) 4089314..4089409 + 96 Protein_3898 dienelactone hydrolase family protein -
QJP96_RS19885 (4089555) 4089555..4090787 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP96_RS19890 (4090828) 4090828..4092108 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280506 WP_001297643.1 NZ_CP124483:c4088361-4088074 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280506 WP_000063156.1 NZ_CP124483:c4088087-4087785 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References