Detailed information of TA system TA280504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3748777..3750466
• Replicon: chromosome
• Accession: NZ_CP124483
• Organism: Escherichia coli strain AVS0575

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP96_RS18265
• Protein ID: WP_000365807.1
• Coordinates: 3748777..3749697 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP96_RS18270
• Protein ID: WP_001295795.1
• Coordinates: 3749684..3750466 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP96_RS18225 (3744250)	3744250..3744960	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP96_RS18230 (3745267)	3745267..3745596	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP96_RS18235 (3745608)	3745608..3745774	-	167	Protein_3578	tail fiber assembly protein	-
QJP96_RS18240 (3745845)	3745845..3746459	-	615	WP_001019923.1	YagU family protein	-
QJP96_RS18245 (3746674)	3746674..3746859	-	186	WP_000146240.1	hypothetical protein	-
QJP96_RS18250 (3746908)	3746908..3747066	+	159	Protein_3581	integrase	-
QJP96_RS18255 (3747293)	3747293..3747628	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP96_RS18260 (3747836)	3747836..3748612	+	777	WP_000171155.1	site-specific integrase	-
QJP96_RS18265 (3748777)	3748777..3749697	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP96_RS18270 (3749684)	3749684..3750466	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP96_RS18275 (3750750)	3750750..3753848	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3708564..3757529	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280504 WP_000365807.1 NZ_CP124483:c3749697-3748777 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280504 WP_001295795.1 NZ_CP124483:c3750466-3749684 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0