Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2501701..2502344 | Replicon | chromosome |
| Accession | NC_018142 | ||
| Organism | Propionibacterium propionicum F0230a | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A4P8ZRW0 |
| Locus tag | HMPREF9154_RS11145 | Protein ID | WP_014847290.1 |
| Coordinates | 2501943..2502344 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A4P8ZS27 |
| Locus tag | HMPREF9154_RS11140 | Protein ID | WP_014847289.1 |
| Coordinates | 2501701..2501946 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMPREF9154_RS11110 | 2497545..2498513 | - | 969 | WP_014847283.1 | WYL domain-containing protein | - |
| HMPREF9154_RS11115 | 2498612..2498995 | + | 384 | WP_014847284.1 | VOC family protein | - |
| HMPREF9154_RS11120 | 2499101..2500396 | + | 1296 | WP_051015025.1 | DUF4143 domain-containing protein | - |
| HMPREF9154_RS11125 | 2500768..2500935 | - | 168 | WP_014847286.1 | 50S ribosomal protein L33 | - |
| HMPREF9154_RS11130 | 2500937..2501173 | - | 237 | WP_014847287.1 | 50S ribosomal protein L28 | - |
| HMPREF9154_RS11135 | 2501258..2501506 | + | 249 | WP_041697718.1 | type B 50S ribosomal protein L31 | - |
| HMPREF9154_RS11140 | 2501701..2501946 | + | 246 | WP_014847289.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| HMPREF9154_RS11145 | 2501943..2502344 | + | 402 | WP_014847290.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HMPREF9154_RS11150 | 2502430..2503128 | - | 699 | WP_014847291.1 | 50S ribosomal protein L1 | - |
| HMPREF9154_RS11155 | 2503212..2503640 | - | 429 | WP_014847292.1 | 50S ribosomal protein L11 | - |
| HMPREF9154_RS11160 | 2503737..2504522 | - | 786 | WP_014847293.1 | transcription termination/antitermination protein NusG | - |
| HMPREF9154_RS15695 | 2504519..2505103 | - | 585 | WP_081490305.1 | preprotein translocase subunit SecE | - |
| HMPREF9154_RS11175 | 2505240..2506262 | - | 1023 | WP_014847295.1 | UDP-N-acetylmuramate dehydrogenase | - |
| HMPREF9154_RS11180 | 2506255..2506668 | - | 414 | WP_014847296.1 | MaoC family dehydratase | - |
| HMPREF9154_RS11185 | 2506661..2507089 | - | 429 | WP_014847297.1 | MaoC family dehydratase N-terminal domain-containing protein | - |
| HMPREF9154_RS11190 | 2507160..2507330 | - | 171 | WP_014847298.1 | 50S ribosomal protein L33 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 13978.00 Da Isoelectric Point: 5.6079
>T28050 WP_014847290.1 NC_018142:2501943-2502344 [Arachnia propionica F0230a]
MIVDPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP
MIVDPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP
Download Length: 402 bp
>T28050 NC_018142:2501943-2502344 [Arachnia propionica F0230a]
ATGATCGTCGACCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCCGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
ATGATCGTCGACCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCCGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8705.75 Da Isoelectric Point: 4.5816
>AT28050 WP_014847289.1 NC_018142:2501701-2501946 [Arachnia propionica F0230a]
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R
Download Length: 246 bp
>AT28050 NC_018142:2501701-2501946 [Arachnia propionica F0230a]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCCTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCCTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P8ZRW0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P8ZS27 |