Detailed information of TA system TA028049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2179198..2179763
• Replicon: chromosome
• Accession: NC_018142
• Organism: Propionibacterium propionicum F0230a

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A4P8ZSL9
• Locus tag: HMPREF9154_RS09570
• Protein ID: WP_014846982.1
• Coordinates: 2179198..2179545 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HMPREF9154_RS09575
• Protein ID: WP_041697619.1
• Coordinates: 2179545..2179763 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF9154_RS09565	2176102..2178132	+	2031	WP_123824201.1	hypothetical protein	-
HMPREF9154_RS09570	2179198..2179545	-	348	WP_014846982.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HMPREF9154_RS09575	2179545..2179763	-	219	WP_041697619.1	ribbon-helix-helix domain-containing protein	Antitoxin
HMPREF9154_RS09580	2179910..2182759	-	2850	WP_014846984.1	vitamin B12-dependent ribonucleotide reductase	-
HMPREF9154_RS09585	2182797..2183333	-	537	WP_014846985.1	transcriptional regulator NrdR	-
HMPREF9154_RS09590	2183532..2183861	-	330	WP_123824199.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-37)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12461.49 Da
• Isoelectric Point: 11.7369

>T28049 WP_014846982.1 NC_018142:c2179545-2179198 [Arachnia propionica F0230a]
VLRGEIRLVDLEPARAGEADKRRPAIIVSNNRANTVAARLGRGVVTVVPVTSNTARVFPFQVLLTADEVGIRLDSKAQAE
QVRAVSVDRIGPVIGRLPARLVAQLDEALRLHLQL

Nucleotide

• Length: 348 bp

>T28049 NC_018142:c2179545-2179198 [Arachnia propionica F0230a]
GTGCTCCGCGGCGAGATCCGGCTGGTCGATCTGGAGCCCGCACGGGCGGGAGAGGCAGACAAGCGTCGTCCGGCGATCAT
CGTCAGCAACAACCGCGCCAACACCGTCGCCGCTCGACTCGGGCGAGGCGTGGTCACGGTCGTCCCCGTCACCAGTAATA
CCGCGCGGGTCTTTCCGTTTCAGGTGCTTCTCACCGCGGATGAGGTCGGCATCCGCTTGGATTCCAAGGCCCAGGCCGAA
CAGGTCCGAGCGGTGTCAGTCGACCGCATCGGCCCGGTGATCGGGCGCCTTCCCGCCCGCCTGGTCGCCCAACTGGATGA
GGCGCTCCGGCTGCACCTTCAGCTCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7591.42 Da
• Isoelectric Point: 4.0390

>AT28049 WP_041697619.1 NC_018142:c2179763-2179545 [Arachnia propionica F0230a]
VKLSVSLSPSEVAVLDKYAQSAGLKSRSAAIQQAIKLLGDPDLEDAYTAAWQEWEDAGEAEAWAATVADGVK

Nucleotide

• Length: 219 bp

>AT28049 NC_018142:c2179763-2179545 [Arachnia propionica F0230a]
GTGAAGTTGAGCGTGAGTCTGTCGCCGAGCGAGGTCGCCGTGCTCGACAAGTACGCACAGTCTGCGGGTTTGAAGTCACG
ATCGGCGGCGATCCAACAGGCCATCAAGCTGCTGGGCGATCCCGACCTGGAGGATGCCTACACCGCTGCCTGGCAGGAGT
GGGAGGACGCCGGAGAGGCCGAGGCCTGGGCGGCCACCGTCGCCGACGGGGTGAAGTAG

Structures

Toxin

• AlphaFold DB: A0A4P8ZSL9